Laura Bush served as the First Lady of the United States from 2001 to 2009, advocating for health, education, and literacy. She established the annual National Book Festival and championed women's causes through various initiatives.
This is based on winning 38 head-to-head matchups with other famous people, but also losing 73 head-to-head matchups.
Most recently Laura Bush lost a matchup to David Schwimmer (#305) voted by someone from Canada.